Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)

Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)

Leaves of herbarium specimen material of Vepris onanae, collected in Cameroon, have yielded two undescribed 2-quinolines, onanaenine A (1) and onanaenine B (2), alongside the known 6,7-dimethoxy-N-methylflindersine (3), evoxanthine (4), 6-methoxy-tecleanthine (5) and polybotrin. Compounds 1 and 2 we...

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Main Author: Olaranont Y.
Other Authors: Mahidol University
Format: Article
Published: 2023
Subjects:
Biochemistry, Genetics and Molecular Biology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/88302
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spelling th-mahidol.883022023-08-14T01:01:06Z Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae) Olaranont Y. Mahidol University Biochemistry, Genetics and Molecular Biology Leaves of herbarium specimen material of Vepris onanae, collected in Cameroon, have yielded two undescribed 2-quinolines, onanaenine A (1) and onanaenine B (2), alongside the known 6,7-dimethoxy-N-methylflindersine (3), evoxanthine (4), 6-methoxy-tecleanthine (5) and polybotrin. Compounds 1 and 2 were not cytotoxic against FM55 melanoma cells at a concentration up to 200 µM, and they did not show signs of stimulating fibroblast skin cells at concentrations, up to 20 µM. Vepris onanae, the source of the two new 2-quinoline alkaloids, is at high risk of extinction, being near-endemic to the threatened Bali-Ngemba forest of NW Region Cameroon. Bali Ngemba has already seen the global extinction of Vepris bali, before it could be researched for new compounds. 2023-08-13T18:01:06Z 2023-08-13T18:01:06Z 2023-10-01 Article Phytochemistry Letters Vol.57 (2023) , 1-4 10.1016/j.phytol.2023.07.010 18767486 18743900 2-s2.0-85166647160 https://repository.li.mahidol.ac.th/handle/123456789/88302 SCOPUS
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Olaranont Y.
Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
description Leaves of herbarium specimen material of Vepris onanae, collected in Cameroon, have yielded two undescribed 2-quinolines, onanaenine A (1) and onanaenine B (2), alongside the known 6,7-dimethoxy-N-methylflindersine (3), evoxanthine (4), 6-methoxy-tecleanthine (5) and polybotrin. Compounds 1 and 2 were not cytotoxic against FM55 melanoma cells at a concentration up to 200 µM, and they did not show signs of stimulating fibroblast skin cells at concentrations, up to 20 µM. Vepris onanae, the source of the two new 2-quinoline alkaloids, is at high risk of extinction, being near-endemic to the threatened Bali-Ngemba forest of NW Region Cameroon. Bali Ngemba has already seen the global extinction of Vepris bali, before it could be researched for new compounds.
author2 Mahidol University
author_facet Mahidol University
Olaranont Y.
format Article
author Olaranont Y.
author_sort Olaranont Y.
title Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
title_short Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
title_full Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
title_fullStr Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
title_full_unstemmed Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
title_sort undescribed 2-quinolines, onanaenine a and b, from cameroonian vepris onanae (rutaceae)
publishDate 2023
url https://repository.li.mahidol.ac.th/handle/123456789/88302
_version_ 1781413987980673024

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