Synthesis and in Vitro Evaluation of 9-Anilino-3,6-diaminoacridines Active Against a Multidrug-Resistant Strain of the Malaria Parasite Plasmodium falciparum

• المؤلفون الرئيسيون: Swarna A. Gamage, Nisana Tepsiri, Prapon Wilairat, Stanley J. Wojcik, David P. Figgitt, Raymond K. Ralph, William A. Denny
• مؤلفون آخرون: School of Medicine, University of Auckland
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/9512

A series of 9-anilinoacridines have been prepared and evaluated for their activity against a multidrug-resistant K1 strain of the malaria parasite Plasmodium falciparum in erythrocyte suspensions. 3,6-Diamino substitution on the acridine ring resulted in lower mammalian cell cytotoxicity and higher...