The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription

by Morin B., Coutard B., Lelke M., Ferron F., Kerber R., Jamal S., Frangeul A., Baronti C., Charrel R., de Lamballerie X., Vonrhein C., Lescar J., Bricogne G., Günther S., Canard B.
Published 2020

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis

by Zhong, W, Cui, L, Goh, B.C, Cai, Q, Ho, P, Chionh, Y.H, Yuan, M, Sahili, A.E, Fothergill-Gilmore, L.A, Walkinshaw, M.D, Lescar, J, Dedon, P.C
Published 2020

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

by Tay M.Y.F., Smith K., Ng I.H.W., Chan K.W.K., Zhao Y., Ooi E.E., Lescar J., Luo D., Jans D.A., Forwood J.K., Vasudevan S.G.
Published 2018

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

by Manzoni, G, Marinach, C, Topçu, S, Briquet, S, Grand, M, Tolle, M, Gransagne, M, Lescar, J, Andolina, C, Franetich, J.-F, Zeisel, M.B, Huby, T, Rubinstein, E, Snounou, G, Mazier, D, Nosten, F, Baumert, T.F, Silvie, O
Published 2020

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

by Zhao Y., Soh T.S., Zheng J., Chan K.W.K., Phoo W.W., Lee C.C., Tay M.Y.F., Swaminathan K., Cornvik T.C., Lim S.P., Shi P.-Y., Lescar J., Vasudevan S.G., Luo D.
Published 2018

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

by Lim S.P., Noble C.G., Seh C.C., Soh T.S., El Sahili A., Chan G.K.Y., Lescar J., Arora R., Benson T., Nilar S., Manjunatha U., Wan K.F., Dong H., Xie X., Shi P.-Y., Yokokawa F.
Published 2019

Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation

by Gu, Y., Koh, R.W.K., Lai, M.L., Pochinco, D., Teo, R.Z.C., Chan, M., Murali, T.M., Liew, C.W., Wong, Y.H., Gascoigne, N.R.J., Wood, K.J., Lescar, J., Nickerson, P., MacAry, P.A., Vathsala, A.
Published 2021