Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

• Main Authors: Lim S.P., Noble C.G., Seh C.C., Soh T.S., El Sahili A., Chan G.K.Y., Lescar J., Arora R., Benson T., Nilar S., Manjunatha U., Wan K.F., Dong H., Xie X., Shi P.-Y., Yokokawa F.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: nonstructural protein 5; RNA directed RNA polymerase; antivirus agent; NS5 protein, dengue virus; nucleic acid synthesis inhibitor; viral protein; allosterism; antiviral therapy; Article; binding affinity; biochemical analysis; CC50; controlled study; Dengue virus; EC50; enzyme activity; enzyme assay; enzyme inhibition assay; Flavivirus; gene expression; IC50; luciferase assay; nonhuman; protein expression; reverse genetics; virus morphology; virus replication; X ray crystallography; Zika virus; A-549 cell line; antagonists and inhibitors; chemistry; dengue; drug design; drug effects; human; protein domain; surface plasmon resonance; A549 Cells; Antiviral Agents; Crystallography, X-Ray; Dengue; Dengue Virus; Drug Design; Humans; Nucleic Acid Synthesis Inhibitors; Protein Domains; RNA Replicase; Surface Plasmon Resonance; Viral Nonstructural Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161910
• Institution: National University of Singapore

10.1371/journal.ppat.1005737