Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
10.1371/journal.ppat.1005737
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sg-nus-scholar.10635-1619102024-11-11T20:12:56Z Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Lim S.P. Noble C.G. Seh C.C. Soh T.S. El Sahili A. Chan G.K.Y. Lescar J. Arora R. Benson T. Nilar S. Manjunatha U. Wan K.F. Dong H. Xie X. Shi P.-Y. Yokokawa F. MICROBIOLOGY AND IMMUNOLOGY DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) BIOLOGICAL SCIENCES DUKE-NUS MEDICAL SCHOOL nonstructural protein 5 RNA directed RNA polymerase antivirus agent NS5 protein, dengue virus nucleic acid synthesis inhibitor RNA directed RNA polymerase viral protein allosterism antiviral therapy Article binding affinity biochemical analysis CC50 controlled study Dengue virus EC50 enzyme activity enzyme assay enzyme inhibition assay Flavivirus gene expression IC50 luciferase assay nonhuman protein expression reverse genetics virus morphology virus replication X ray crystallography Zika virus A-549 cell line antagonists and inhibitors chemistry dengue Dengue virus drug design drug effects human protein domain surface plasmon resonance A549 Cells Antiviral Agents Crystallography, X-Ray Dengue Dengue Virus Drug Design Humans Nucleic Acid Synthesis Inhibitors Protein Domains RNA Replicase Surface Plasmon Resonance Viral Nonstructural Proteins 10.1371/journal.ppat.1005737 PLoS Pathogens 12 8 e1005737 2019-11-08T06:48:02Z 2019-11-08T06:48:02Z 2016 Article Lim S.P., Noble C.G., Seh C.C., Soh T.S., El Sahili A., Chan G.K.Y., Lescar J., Arora R., Benson T., Nilar S., Manjunatha U., Wan K.F., Dong H., Xie X., Shi P.-Y., Yokokawa F. (2016). Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. PLoS Pathogens 12 (8) : e1005737. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1005737 15537366 https://scholarbank.nus.edu.sg/handle/10635/161910 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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| topic |
nonstructural protein 5 RNA directed RNA polymerase antivirus agent NS5 protein, dengue virus nucleic acid synthesis inhibitor RNA directed RNA polymerase viral protein allosterism antiviral therapy Article binding affinity biochemical analysis CC50 controlled study Dengue virus EC50 enzyme activity enzyme assay enzyme inhibition assay Flavivirus gene expression IC50 luciferase assay nonhuman protein expression reverse genetics virus morphology virus replication X ray crystallography Zika virus A-549 cell line antagonists and inhibitors chemistry dengue Dengue virus drug design drug effects human protein domain surface plasmon resonance A549 Cells Antiviral Agents Crystallography, X-Ray Dengue Dengue Virus Drug Design Humans Nucleic Acid Synthesis Inhibitors Protein Domains RNA Replicase Surface Plasmon Resonance Viral Nonstructural Proteins |
| spellingShingle |
nonstructural protein 5 RNA directed RNA polymerase antivirus agent NS5 protein, dengue virus nucleic acid synthesis inhibitor RNA directed RNA polymerase viral protein allosterism antiviral therapy Article binding affinity biochemical analysis CC50 controlled study Dengue virus EC50 enzyme activity enzyme assay enzyme inhibition assay Flavivirus gene expression IC50 luciferase assay nonhuman protein expression reverse genetics virus morphology virus replication X ray crystallography Zika virus A-549 cell line antagonists and inhibitors chemistry dengue Dengue virus drug design drug effects human protein domain surface plasmon resonance A549 Cells Antiviral Agents Crystallography, X-Ray Dengue Dengue Virus Drug Design Humans Nucleic Acid Synthesis Inhibitors Protein Domains RNA Replicase Surface Plasmon Resonance Viral Nonstructural Proteins Lim S.P. Noble C.G. Seh C.C. Soh T.S. El Sahili A. Chan G.K.Y. Lescar J. Arora R. Benson T. Nilar S. Manjunatha U. Wan K.F. Dong H. Xie X. Shi P.-Y. Yokokawa F. Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling |
| description |
10.1371/journal.ppat.1005737 |
| author2 |
MICROBIOLOGY AND IMMUNOLOGY |
| author_facet |
MICROBIOLOGY AND IMMUNOLOGY Lim S.P. Noble C.G. Seh C.C. Soh T.S. El Sahili A. Chan G.K.Y. Lescar J. Arora R. Benson T. Nilar S. Manjunatha U. Wan K.F. Dong H. Xie X. Shi P.-Y. Yokokawa F. |
| format |
Article |
| author |
Lim S.P. Noble C.G. Seh C.C. Soh T.S. El Sahili A. Chan G.K.Y. Lescar J. Arora R. Benson T. Nilar S. Manjunatha U. Wan K.F. Dong H. Xie X. Shi P.-Y. Yokokawa F. |
| author_sort |
Lim S.P. |
| title |
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling |
| title_short |
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling |
| title_full |
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling |
| title_fullStr |
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling |
| title_full_unstemmed |
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling |
| title_sort |
potent allosteric dengue virus ns5 polymerase inhibitors: mechanism of action and resistance profiling |
| publishDate |
2019 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/161910 |
| _version_ |
1821188890407469056 |