West Nile virus drug discovery

by Lim, S.P, Shi, P.-Y
Published 2020

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication

by Poh, M.K., Shui, G., Xie, X., Shi, P.-Y., Wenk, M.R., Gu, F.
Published 2014

West nile virus experimental evolution in vivo and the trade-off hypothesis

by Deardorff E.R., Fitzpatrick K.A., Jerzak G.V.S., Shi P.-Y., Kramer L.D., Ebel G.D.
Published 2019

Crystal structure of the Dengue virus methyltransferase bound to a 5?-capped octameric RNA

by Yap L.J., Luo D., Chung K.Y., Lim S.P., Bodenreider C., Noble C., Shi P.-Y., Lescar J.
Published 2019

A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds

by Martín-Acebes M.A., Blázquez A.-B., de Oya N.J., Escribano-Romero E., Shi P.-Y., Saiz J.-C.
Published 2019

Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

by Shan, C, Ortiz, D.A, Yang, Y, Wong, S.J, Kramer, L.D, Shi, P.-Y, Loeffelholz, M.J, Ren, P
Published 2020

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

by Li X.-D., Shan C., Deng C.-L., Ye H.-Q., Shi P.-Y., Yuan Z.-M., Gong P., Zhang B.
Published 2019

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

by Whitehorn J., Yacoub S., Anders K.L., Macareo L.R., Cassetti M.C., Nguyen Van V.C., Shi P.-Y., Wills B., Simmons C.P.
Published 2019

Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1

by Zou, G., Kukkaro, P., Lok, S.-M., Ng, J.K.W., Tan, G.K., Hanson, B.J., Alonso, S., MacAry, P.A., Shi, P.-Y.
Published 2016

Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

by Simmons C.P., Wolbers M., Nguyen M.N., Whitehorn J., Shi P.Y., Young P., Petric R., Nguyen V.V.C., Farrar J., Wills B.
Published 2019

A small molecule fusion inhibitor of dengue virus

by Poh, M.K., Yip, A., Zhang, S., Ma, N.L., Shi, P.-Y., Schul, W., Wenk, M.R., Smit, J.M., Wilschut, J., Priestle, J.P.
Published 2011

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

by Zhao Y., Soh T.S., Chan K.W.K., Fung S.S.Y., Swaminathan K., Lim S.P., Shi P.-Y., Huber T., Lescar J., Luo D., Vasudevan S.G.
Published 2020

A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

by Grant, D., Tan, G.K., Qing, M., Ng, J.K.W., Yip, A., Zou, G., Xie, X., Yuan, Z.Y., Schreiber, J., Schul, W., Shi, P.-Y., Alonso, S.
Published 2016

Partial genetic characterization of West Nile virus strains, New York State, 2000

by Ebel, G.D, Dupuis II, A.P, Ngo, K, Nicholas, D, Kauffman, E, Jones, S.A, Young, D, Maffei, J, Shi, P.-Y, Bernard, K, Kramer, L.D
Published 2020

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

by Lim, X.-N., Shan, C., Marzinek, J.K., Dong, H., Ng, T.S., Ooi, J.S.G., Fibriansah, G., Wang, J., Verma, C.S., Bond, P.J., Shi, P.-Y., Lok, S.-M.
Published 2021

2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

by Dong, H., Chang, D.C., Hua, M.H.C., Lim, S.P., Chionh, Y.H., Hia, F., Lee, Y.H., Kukkaro, P., Lok, S.-M., Dedon, P.C., Shi, P.-Y.
Published 2016

Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

by Pompon J., Manuel M., Ng G.K., Wong B., Shan C., Manokaran G., Soto-Acosta R., Bradrick S.S., Ooi E.E., Missé D., Shi P.-Y., Garcia-Blanco M.A.
Published 2020

Understanding zika virus stability and developing a chimeric vaccine through functional analysis

by Xie, X, Yang, Y, Muruato, A.E, Zou, J, Shan, C, Nunes, B.T.D, Medeiros, D.B.A, Vasconcelos, P.F.C, Weaver, S.C, Rossi, S.L, Shi, P.-Y
Published 2020

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

by Züst R., Li S.-H., Xie X., Velumani S., Chng M., Toh Y.-X., Zou J., Dong H., Shan C., Pang J., Qin C.-F., Newell E.W., Shi P.-Y., Fink K.
Published 2019

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

by Song, K.-Y, Zhao, H, Jiang, Z.-Y, Li, X.-F, Deng, Y.-Q, Jiang, T, Zhu, S.-Y, Shi, P.-Y, Zhang, B, Zhang, F.-C, Qin, E.-D, Qin, C.-F
Published 2020