Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

• Main Authors: Zhao Y., Soh T.S., Chan K.W.K., Fung S.S.Y., Swaminathan K., Lim S.P., Shi P.-Y., Huber T., Lescar J., Luo D., Vasudevan S.G.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: methyltransferase; nonstructural protein 5; NS5 protein, dengue virus; recombinant protein; virus protein; virus RNA; amino acid substitution; Article; controlled study; Dengue virus; enzyme activity; nonhuman; plasticity; priority journal; protein conformation; protein domain; protein expression; site directed mutagenesis; structure activity relation; virus mutation; virus replication; amino acid sequence; animal; cell line; chemistry; Cricetulus; gene expression; genetics; human; metabolism; molecular dynamics; molecular genetics; mutation; physiology; protein secondary structure; protein tertiary structure; sequence alignment; X ray crystallography; Amino Acid Sequence; Animals; Cell Line; Crystallography, X-Ray; Dengue Virus; Gene Expression; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; RNA, Viral; Sequence Alignment; Viral Nonstructural Proteins; Virus Replication
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175294
• Institution: National University of Singapore

10.1128/JVI.01239-15