Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

10.1128/JVI.01239-15

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Main Authors:	Zhao Y., Soh T.S., Chan K.W.K., Fung S.S.Y., Swaminathan K., Lim S.P., Shi P.-Y., Huber T., Lescar J., Luo D., Vasudevan S.G.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	methyltransferase nonstructural protein 5 NS5 protein, dengue virus recombinant protein virus protein virus RNA amino acid substitution Article controlled study Dengue virus enzyme activity nonhuman plasticity priority journal protein conformation protein domain protein expression site directed mutagenesis structure activity relation virus mutation virus replication amino acid sequence animal cell line chemistry Cricetulus gene expression genetics human metabolism molecular dynamics molecular genetics mutation physiology protein secondary structure protein tertiary structure sequence alignment X ray crystallography Amino Acid Sequence Animals Cell Line Crystallography, X-Ray Dengue Virus Gene Expression Humans Molecular Dynamics Simulation Molecular Sequence Data Mutation Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins RNA, Viral Sequence Alignment Viral Nonstructural Proteins Virus Replication
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175294
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1752942024-04-03T05:13:50Z Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication Zhao Y. Soh T.S. Chan K.W.K. Fung S.S.Y. Swaminathan K. Lim S.P. Shi P.-Y. Huber T. Lescar J. Luo D. Vasudevan S.G. DUKE-NUS MEDICAL SCHOOL BIOLOGICAL SCIENCES methyltransferase nonstructural protein 5 NS5 protein, dengue virus recombinant protein virus protein virus RNA amino acid substitution Article controlled study Dengue virus enzyme activity nonhuman plasticity priority journal protein conformation protein domain protein expression site directed mutagenesis structure activity relation virus mutation virus replication amino acid sequence animal cell line chemistry Cricetulus Dengue virus gene expression genetics human metabolism molecular dynamics molecular genetics mutation physiology protein secondary structure protein tertiary structure sequence alignment virus replication X ray crystallography Amino Acid Sequence Animals Cell Line Cricetulus Crystallography, X-Ray Dengue Virus Gene Expression Humans Molecular Dynamics Simulation Molecular Sequence Data Mutation Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins RNA, Viral Sequence Alignment Viral Nonstructural Proteins Virus Replication 10.1128/JVI.01239-15 Journal of Virology 89 20 10717-10721 2020-09-09T07:20:38Z 2020-09-09T07:20:38Z 2015 Article Zhao Y., Soh T.S., Chan K.W.K., Fung S.S.Y., Swaminathan K., Lim S.P., Shi P.-Y., Huber T., Lescar J., Luo D., Vasudevan S.G. (2015). Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication. Journal of Virology 89 (20) : 10717-10721. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.01239-15 0022-538X https://scholarbank.nus.edu.sg/handle/10635/175294 American Society for Microbiology Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	methyltransferase nonstructural protein 5 NS5 protein, dengue virus recombinant protein virus protein virus RNA amino acid substitution Article controlled study Dengue virus enzyme activity nonhuman plasticity priority journal protein conformation protein domain protein expression site directed mutagenesis structure activity relation virus mutation virus replication amino acid sequence animal cell line chemistry Cricetulus Dengue virus gene expression genetics human metabolism molecular dynamics molecular genetics mutation physiology protein secondary structure protein tertiary structure sequence alignment virus replication X ray crystallography Amino Acid Sequence Animals Cell Line Cricetulus Crystallography, X-Ray Dengue Virus Gene Expression Humans Molecular Dynamics Simulation Molecular Sequence Data Mutation Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins RNA, Viral Sequence Alignment Viral Nonstructural Proteins Virus Replication
spellingShingle	methyltransferase nonstructural protein 5 NS5 protein, dengue virus recombinant protein virus protein virus RNA amino acid substitution Article controlled study Dengue virus enzyme activity nonhuman plasticity priority journal protein conformation protein domain protein expression site directed mutagenesis structure activity relation virus mutation virus replication amino acid sequence animal cell line chemistry Cricetulus Dengue virus gene expression genetics human metabolism molecular dynamics molecular genetics mutation physiology protein secondary structure protein tertiary structure sequence alignment virus replication X ray crystallography Amino Acid Sequence Animals Cell Line Cricetulus Crystallography, X-Ray Dengue Virus Gene Expression Humans Molecular Dynamics Simulation Molecular Sequence Data Mutation Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins RNA, Viral Sequence Alignment Viral Nonstructural Proteins Virus Replication Zhao Y. Soh T.S. Chan K.W.K. Fung S.S.Y. Swaminathan K. Lim S.P. Shi P.-Y. Huber T. Lescar J. Luo D. Vasudevan S.G. Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
description	10.1128/JVI.01239-15
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Zhao Y. Soh T.S. Chan K.W.K. Fung S.S.Y. Swaminathan K. Lim S.P. Shi P.-Y. Huber T. Lescar J. Luo D. Vasudevan S.G.
format	Article
author	Zhao Y. Soh T.S. Chan K.W.K. Fung S.S.Y. Swaminathan K. Lim S.P. Shi P.-Y. Huber T. Lescar J. Luo D. Vasudevan S.G.
author_sort	Zhao Y.
title	Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
title_short	Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
title_full	Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
title_fullStr	Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
title_full_unstemmed	Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication
title_sort	flexibility of ns5 methyltransferase-polymerase linker region is essential for dengue virus replication
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175294
_version_	1795301117535453184

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

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