Alternative Splicing Signatures in RNA-seq Data: Percent Spliced in (PSI)

by Schafer S., Miao K., Benson C.C., Heinig M., Cook S.A., Hubner N.
Published 2018

Reply: Normalization procedures and detection of linkage signal in genetical-genomics experiments [6]

by Petretto E., Mangion J., Cook S.A., Aitman T.J., Pravenec M., Schulz H., Fischer J., Hubner N.
Published 2018

Genome-wide co-expression analysis in multiple tissues

by Grieve I.C., Dickens N.J., Pravenec M., Kren V., Hubner N., Cook S.A., Aitman T.J., Petretto E., Mangion J.
Published 2018

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

by Langley S.R., Bottolo L., Kunes J., Zicha J., Zidek V., Hubner N., Cook S.A., Pravenec M., Aitman T.J., Petretto E.
Published 2018

Distribution and functional impact of DNA copy number variation in the rat

by Guryev V., Saar K., Adamovic T., Verheul M., Van Heesch S.A.A.C., Cook S., Pravenec M., Aitman T., Jacob H., Shull J.D., Hubner N., Cuppen E.
Published 2018

New insights into the genetic control of gene expression using a bayesian multi-tissue approach

by Petretto E., Bottolo L., Langley S.R., Heinig M., McDermott-Roe C., Sarwar R., Pravenec M., Hübner N., Aitman T.J., Cook S.A., Richardson S.
Published 2018

Heritability and tissue specificity of expression quantitative trait loci

by Petretto E., Mangion J., Dickens N.J., Cook S.A., Kumaran M.K., Lu H., Fischer J., Maatz H., Kren V., Pravenec M., Hubner N., Aitman T.J.
Published 2018

Translational regulation shapes the molecular landscape of complex disease phenotypes

by Schafer S., Adami E., Heinig M., Rodrigues K.E.C., Kreuchwig F., Silhavy J., Van Heesch S., Simaite D., Rajewsky N., Cuppen E., Pravenec M., Vingron M., Cook S.A., Hubner N.
Published 2016

Natural variation of histone modification and its impact on gene expression in the rat genome

by Rintisch C., Heinig M., Bauerfeind A., Schafer S., Mieth C., Patone G., Hummel O., Chen W., Cook S., Cuppen E., Colom‚-Tatch‚ M., Johannes F., Jansen R.C., Neil H., Werner M., Pravenec M., Vingron M., Hubner N.
Published 2019

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

by Maatz H., Jens M., Liss M., Schafer S., Heinig M., Kirchner M., Adami E., Rintisch C., Dauksaite V., Radke M.H., Selbach M., Barton P.J.R., Cook S.A., Rajewsky N., Gotthardt M., Landthaler M., Hubner N.
Published 2019

Genome-Wide polyadenylation maps reveal dynamic mRNA 3?-End formation in the failing human heart

by Creemers E.E., Bawazeer A., Van Ugalde A.P., Van Deutekom H.W.M., Der Made I., De Groot N.E., Adriaens M.E., Cook S.A., Van Bezzina C.R., Hubner N., Der Velden J., Elkon R., Agami R., Pinto Y.M.
Published 2019

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

by Hinson J.T., Chopra A., Nafissi N., Polacheck W.J., Benson C.C., Swist S., Gorham J., Yang L., Schafer S., Sheng C.C., Haghighi A., Homsy J., Hubner N., Church G., Cook S.A., Linke W.A., Chen C.S., Seidman J.G., Seidman C.E.
Published 2019

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

by Hubner N., Wallace C.A., Zimdahl H., Petretto E., Schulz H., Maciver F., Mueller M., Hummel O., Monti J., Zidek V., Musilova A., Kren V., Causton H., Game L., Born G., Schmidt S., M�ller A., Cook S.A., Kurtz T.W., Whittaker J., Pravenec M., Aitman T.J.
Published 2018

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease

by Monti J., Fischer J., Paskas S., Heinig M., Schulz H., G�sele C., Heuser A., Fischer R., Schmidt C., Schirdewan A., Gross V., Hummel O., Maatz H., Patone G., Saar K., Vingron M., Weldon S.M., Lindpaintner K., Hammock B.D., Rohde K., Dietz R., Cook S.A., Schunck W.-H., Luft F.C., Hubner N.
Published 2018

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy

by Arndt A.-K., Schafer S., Drenckhahn J.-D., Sabeh M.K., Plovie E.R., Caliebe A., Klopocki E., Musso G., Werdich A.A., Kalwa H., Heinig M., Padera R.F., Wassilew K., Bluhm J., Harnack C., Martitz J., Barton P.J., Greutmann M., Berger F., Hubner N., Siebert R., Kramer H.-H., Cook S.A., Macrae C.A., Klaassen S.
Published 2019

Wars2 is a determinant of angiogenesis

by Wang M., Sips P., Khin E., Rotival M., Sun X., Ahmed R., Widjaja A.A., Schafer S., Yusoff P., Choksi P.K., Ko N.S.J., Singh M.K., Epstein D., Guan Y., Houštěk J., Mracek T., Nuskova H., Mikell B., Tan J., Pesce F., Kolar F., Bottolo L., Mancini M., Hubner N., Pravenec M., Petretto E., Macrae C., Cook S.A.
Published 2019

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

by Petretto E., Sarwar R., Grieve I., Lu H., Kumaran M.K., Muckett P.J., Mangion J., Schroen B., Benson M., Punjabi P.P., Prasad S.K., Pennell D.J., Kiesewetter C., Tasheva E.S., Corpuz L.M., Webb M.D., Conrad G.W., Kurtz T.W., Kren V., Fischer J., Hubner N., Pinto Y.M., Pravenec M., Aitman T.J., Cook S.A.
Published 2018

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

by Heinig M., Adriaens M.E., Schafer S., van Deutekom H.W.M., Lodder E.M., Ware J.S., Schneider V., Felkin L.E., Creemers E.E., Meder B., Katus H.A., Rühle F., Stoll M., Cambien F., Villard E., Charron P., Varro A., Bishopric N.H., George A.L., dos Remedios C., Moreno-Moral A., Pesce F., Bauerfeind A., Rüschendorf F., Rintisch C., Petretto E., Barton P.J., Cook S.A., Pinto Y.M., Bezzina C.R., Hubner N.
Published 2019

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

by McDermott-Roe C., Ye J., Ahmed R., Sun X.-M., Seraf�n A., Ware J., Bottolo L., Muckett P., Ca�as X., Zhang J., Rowe G.C., Buchan R., Lu H., Braithwaite A., Mancini M., Hauton D., Mart� R., Garc�-Arum� E., Hubner N., Jacob H., Serikawa T., Zidek V., Papousek F., Kolar F., Cardona M., Ruiz-Meana M., Garc�a-Dorado D., Comella J.X., Felkin L.E., Barton P.J.R., Arany Z., Pravenec M., Petretto E., Sanchis D., Cook S.A.
Published 2018

The CRAPome: A contaminant repository for affinity purification-mass spectrometry data

by Mellacheruvu, D., Wright, Z., Couzens, A.L., Lambert, J.-P., St-Denis, N.A., Li, T., Miteva, Y.V., Hauri, S., Sardiu, M.E., Low, T.Y., Halim, V.A., Bagshaw, R.D., Hubner, N.C., Al-Hakim, A., Bouchard, A., Faubert, D., Fermin, D., Dunham, W.H., Goudreault, M., Lin, Z.-Y., Badillo, B.G., Pawson, T., Durocher, D., Coulombe, B., Aebersold, R., Superti-Furga, G., Colinge, J., Heck, A.J.R., Choi, H., Gstaiger, M., Mohammed, S., Cristea, I.M., Bennett, K.L., Washburn, M.P., Raught, B., Ewing, R.M., Gingras, A.-C., Nesvizhskii, A.I.
Published 2014