Alternative Splicing Signatures in RNA-seq Data: Percent Spliced in (PSI)

by Schafer S., Miao K., Benson C.C., Heinig M., Cook S.A., Hubner N.
Published 2018

New insights into the genetic control of gene expression using a bayesian multi-tissue approach

by Petretto E., Bottolo L., Langley S.R., Heinig M., McDermott-Roe C., Sarwar R., Pravenec M., Hübner N., Aitman T.J., Cook S.A., Richardson S.
Published 2018

Translational regulation shapes the molecular landscape of complex disease phenotypes

by Schafer S., Adami E., Heinig M., Rodrigues K.E.C., Kreuchwig F., Silhavy J., Van Heesch S., Simaite D., Rajewsky N., Cuppen E., Pravenec M., Vingron M., Cook S.A., Hubner N.
Published 2016

Natural variation of histone modification and its impact on gene expression in the rat genome

by Rintisch C., Heinig M., Bauerfeind A., Schafer S., Mieth C., Patone G., Hummel O., Chen W., Cook S., Cuppen E., Colom‚-Tatch‚ M., Johannes F., Jansen R.C., Neil H., Werner M., Pravenec M., Vingron M., Hubner N.
Published 2019

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

by Maatz H., Jens M., Liss M., Schafer S., Heinig M., Kirchner M., Adami E., Rintisch C., Dauksaite V., Radke M.H., Selbach M., Barton P.J.R., Cook S.A., Rajewsky N., Gotthardt M., Landthaler M., Hubner N.
Published 2019

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function

by McDermott-Roe C., Leleu M., Rowe G.C., Palygin O., Bukowy J.D., Kuo J., Rech M., Hermans-Beijnsberger S., Schaefer S., Adami E., Creemers E.E., Heinig M., Schroen B., Arany Z., Petretto E., Geurts A.M.
Published 2020

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease

by Monti J., Fischer J., Paskas S., Heinig M., Schulz H., G�sele C., Heuser A., Fischer R., Schmidt C., Schirdewan A., Gross V., Hummel O., Maatz H., Patone G., Saar K., Vingron M., Weldon S.M., Lindpaintner K., Hammock B.D., Rohde K., Dietz R., Cook S.A., Schunck W.-H., Luft F.C., Hubner N.
Published 2018

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy

by Arndt A.-K., Schafer S., Drenckhahn J.-D., Sabeh M.K., Plovie E.R., Caliebe A., Klopocki E., Musso G., Werdich A.A., Kalwa H., Heinig M., Padera R.F., Wassilew K., Bluhm J., Harnack C., Martitz J., Barton P.J., Greutmann M., Berger F., Hubner N., Siebert R., Kramer H.-H., Cook S.A., Macrae C.A., Klaassen S.
Published 2019

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

by Heinig M., Adriaens M.E., Schafer S., van Deutekom H.W.M., Lodder E.M., Ware J.S., Schneider V., Felkin L.E., Creemers E.E., Meder B., Katus H.A., Rühle F., Stoll M., Cambien F., Villard E., Charron P., Varro A., Bishopric N.H., George A.L., dos Remedios C., Moreno-Moral A., Pesce F., Bauerfeind A., Rüschendorf F., Rintisch C., Petretto E., Barton P.J., Cook S.A., Pinto Y.M., Bezzina C.R., Hubner N.
Published 2019

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

by Roberts A.M., Ware J.S., Herman D.S., Schafer S., Baksi J., Bick A.G., Buchan R.J., Walsh R., John S., Wilkinson S., Mazzarotto F., Felkin L.E., Gong S., Macarthur J.A.L., Cunningham F., Flannick J., Gabriel S.B., Altshuler D.M., MacDonald P.S., Heinig M., Keogh A.M., Hayward C.S., Banner N.R., Pennell D.J., O'Regan D.P., San T.R., De Marvao A., Dawes T.J.W., Gulati A., Birks E.J., Yacoub M.H., Radke M., Gotthardt M., Wilson J.G., O'Donnell C.J., Prasad S.K., Barton P.J.R., Fatkin D., Hubner N., Seidman J.G., Seidman C.E., Cook S.A.
Published 2019

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

by Heinig M., Petretto E., Wallace C., Bottolo L., Rotival M., Lu H., Li Y., Sarwar R., Langley S.R., Bauerfeind A., Hummel O., Lee Y.-A., Paskas S., Rintisch C., Saar K., Cooper J., Buchan R., Gray E.E., Cyster J.G., Jeanette Erdmann, Hengstenberg C., Maouche S., Ouwehand W.H., Rice C.M., Samani N.J., Schunkert H., Goodall A.H., Schulz H., Roider H.G., Vingron M., Blankenberg S., M�nzel T., Zeller T., Szymczak S., Ziegler A., Tiret L., Smyth D.J., Pravenec M., Aitman T.J., Cambien F., Clayton D., Todd J.A., Hubner N., Cook S.A., Braund P., Gracey J., Krishnan U., Moore J.S., Nelson C.P., Pollard H., Attwood T., Crisp-Hihn A., Foad N., Jolley J., Lloyd-Jones H., Muir D., Murray E., O'Leary K., Rankin A., Sambrook J., Godfroy T., Brocheton J., Proust C., Schmitz G., Heimerl S., Lugauer I., Belz S., Gulde S., Linsel-Nitschke P., Sager H., Schroeder L., Lundmark P., Syvannen A.-C., Neudert J., Scholz M., Deloukas P., Gray E., Gwilliams R., Niblett D.
Published 2018