Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome

by Distrutti E., Cipriani S., Mencarelli A., Renga B., Fiorucci S.
Published 2019

Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

by Mencarelli, A, Cipriani, S, Francisci, D, Santucci, L, Baldelli, F, Distrutti, E, Fiorucci, S
Published 2020

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

by Mencarelli A., Cipriani S., Renga B., Bruno A., D'Amore C., Distrutti E., Fiorucci S.
Published 2019

The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice

by Mencarelli A., Cipriani S., Renga B., Francisci D., Palladino G., Distrutti E., Baldelli F., Fiorucci S.
Published 2019

The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes

by Renga B., Francisci D., D'Amore C., Schiaroli E., Mencarelli A., Cipriani S., Baldelli F., Fiorucci S.
Published 2019

The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

by Cipriani S., Mencarelli A., Chini M.G., Distrutti E., Renga B., Bifulco G., Baldelli F., Donini A., Fiorucci S.
Published 2019

Probiotics modulate intestinal expression of nuclear receptor and provide Counter-Regulatory signals to Inflammation-Driven adipose tissue activation

by Mencarelli A., Distrutti E., Renga B., D'Amore C., Cipriani S., Palladino G., Donini A., Ricci P., Fiorucci S.
Published 2019

Calcineurin B in CD4+ T Cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway

by Mencarelli, A, Vacca, M, Khameneh, H.J, Acerbi, E, Tay, A, Zolezzi, F, Poidinger, M, Mortellaro, A
Published 2020

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

by Renga B., Mencarelli A., Cipriani S., D'Amore C., Carino A., Bruno A., Francisci D., Zampella A., Distrutti E., Fiorucci S.
Published 2019

The inflammasome adaptor ASC intrinsically limits CD4+ T-cell proliferation to help maintain intestinal homeostasis

by Khameneh, H.J., Leong, K.W.K., Mencarelli, A., Vacca, M., Mambwe, B., Neo, K., Tay, A., Zolezzi, F., Lee, B., Mortellaro, A.
Published 2021

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis

by Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S
Published 2020

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

by Renga B., Mencarelli A., D'Amore C., Cipriani S., D'Auria M.V., Sepe V., Chini M.G., Monti M.C., Bifulco G., Zampella A., Fiorucci S.
Published 2019

Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis

by Mencarelli A., Khameneh H.J., Fric J., Vacca M., El Daker S., Janela B., Tang J.P., Nabti S., Balachander A., Lim T.S., Ginhoux F., Ricciardi-Castagnoli P., Mortellaro A.
Published 2020