Probiotics modulate intestinal expression of nuclear receptor and provide Counter-Regulatory signals to Inflammation-Driven adipose tissue activation

• Main Authors: Mencarelli A., Distrutti E., Renga B., D'Amore C., Cipriani S., Palladino G., Donini A., Ricci P., Fiorucci S.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: adiponectin; cell nucleus receptor; ciprofloxacin; farnesoid X receptor; gamma interferon; interleukin 6; leptin; liver X receptor; metronidazole; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor gamma; pregnane X receptor; probiotic agent; tumor necrosis factor alpha; tumor necrosis factor alpha inhibitor; VSL3; cell receptor; cytokine; farnesoid X-activated receptor; messenger RNA; orphan nuclear receptor; steroid receptor; trinitrobenzenesulfonic acid; abdominal abscess; abdominal fat; adipose tissue; adult; animal experiment; animal model; animal tissue; antiinflammatory activity; article; clinical article; clinical feature; colitis; colon cancer; concentration response; controlled study; Crohn disease; disease course; enteritis; enzyme activation; female; human; human tissue; immunomodulation; inflammation; intestine cell; intestine fistula; male; mouse; nonhuman; protein expression; protein function; protein localization; protein secretion; regulatory mechanism; signal transduction; tissue culture; tissue level; treatment duration; animal; cell culture; chemically induced disorder; drug effect; enzyme immunoassay; enzyme linked immunosorbent assay; genetic transcription; genetics; intestine; mesentery; metabolism; pathology; pathophysiology; reverse transcription polymerase chain reaction; Western blotting; Animalia; Mus; Rodentia; Adipose Tissue; Adult; Animals; Blotting, Western; Cells, Cultured; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoenzyme Techniques; Inflammation; Intestines; Male; Mesentery; Mice; Orphan Nuclear Receptors; PPAR gamma; Probiotics; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Trinitrobenzenesulfonic Acid
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162037
• Institution: National University of Singapore

10.1371/journal.pone.0022978