Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

by Watcharee Amornwatcharapong, Somchart Maenpuen, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Published 2018

Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: Implications for selective inhibition

by Chatchadaporn Pinthong, Somchart Maenpuen, Watcharee Amornwatcharapong, Yongyuth Yuthavong, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Published 2018

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

by Penchit Chitnumsub, Wanwipa Ittarat, Aritsara Jaruwat, Krittikar Noytanom, Watcharee Amornwatcharapong, Wichai Pornthanakasem, Pimchai Chaiyen, Yongyuth Yuthavong, Ubolsree Leartsakulpanich
Published 2018

Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase

by Somchart Maenpuen, Watcharee Amornwatcharapong, Pasupat Krasatong, Jeerus Sucharitakul, Bruce A. Palfey, Yongyuth Yuthavong, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Published 2018

Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold

by Geoffrey Schwertz, Matthias C. Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Watcharee Amornwatcharapong, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Pimchai Chaiyen, François Diederich
Published 2019