Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase

by Manee Chanama, Penchit Chitnumsub, Yongyuth Yuthavong
Published 2018

Pyrimethamine analogue inhibitors of resistance mutants of Plasmodial dihydrofolate reductase

by Ali Sardarian, Kenneth T. Douglas, Penchit Chitnumsub, Worachart Sirawaraporn
Published 2018

Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen

by Penchit Chitnumsub, Jirundon Yuvaniyama, Thippayarat Chahomchuen, Tirayut Vilaivan, Yongyuth Yuthavong
Published 2018

Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

by Watcharee Amornwatcharapong, Somchart Maenpuen, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Published 2018

Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum

by Penchit Chitnumsub, Jirundon Yavaniyama, Jarunee Vanichtanankul, Sumalee Kamchonwongpaisan, Malcolm D. Walkinshaw, Yongyuth Yuthavong
Published 2018

Erratum: Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum (Acta Crystallogra...

by Penchit Chitnumsub, Jirundon Yuvaniyama, Jarunee Vanichtanankul, Sumalee Kamchonwongpaisan, Malcolm D. Walkinshaw, Yongyuth Yuthavong
Published 2018

Identification of a Hotspot Residue for Improving the Thermostability of a Flavin-Dependent Monooxygenase

by Pornkanok Pongpamorn, Pratchaya Watthaisong, Panu Pimviriyakul, Aritsara Jaruwat, Narin Lawan, Penchit Chitnumsub, Pimchai Chaiyen
Published 2020

Trypanosomal dihydrofolate reductase reveals natural antifolate resistance

by Jarunee Vanichtanankul, Supannee Taweechai, Jirundon Yuvaniyama, Tirayut Vilaivan, Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong
Published 2018

Crystal structure of dihydrofolate reductase from Plasmodium vivax: Pyrimethamine displacement linked with mutation-induced resistance

by Palangpon Kongsaeree, Puttapol Khongsuk, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Bongkoch Tarnchompoo, Malcolm D. Walkinshaw, Yongyuth Yuthavong
Published 2018

Structural dynamics and in silico design of pyrazolopyran-based inhibitors against Plasmodium serine hydroxymethyltransferases

by Pitchayathida Mee-udorn, Bodee Nutho, Romchalee Chootrakool, Somchart Maenpuen, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Thanyada Rungrotmongkol
Published 2022

Insights into antifolate resistance from malarial DHFR-TS structures

by Jirundon Yuvaniyama, Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Jarunee Vanichtanankul, Worachart Sirawaraporn, Paul Taylor, Malcolm D. Walkinshaw, Yongyuth Yuthavong
Published 2018

Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

by Rongbao Li, Rachada Sirawaraporn, Penchit Chitnumsub, Worachart Sirawaraporn, Jason Wooden, Francis Athappilly, Stewart Turley, Wim G.J. Hol
Published 2018

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

by Penchit Chitnumsub, Wanwipa Ittarat, Aritsara Jaruwat, Krittikar Noytanom, Watcharee Amornwatcharapong, Wichai Pornthanakasem, Pimchai Chaiyen, Yongyuth Yuthavong, Ubolsree Leartsakulpanich
Published 2018

Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites

by Alireza Sardarian, Kenneth T. Douglas, Martin Read, Paul F G Sims, John E. Hyde, Penchit Chitnumsub, Rachada Sirawaraporn, Worachart Sirawaraporn
Published 2018

Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase

by Somchart Maenpuen, Watcharee Amornwatcharapong, Pasupat Krasatong, Jeerus Sucharitakul, Bruce A. Palfey, Yongyuth Yuthavong, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Published 2018

Mechanism-guided tunnel engineering to increase the efficiency of a flavin-dependent halogenase

by Kridsadakorn Prakinee, Aisaraphon Phintha, Surawit Visitsatthawong, Narin Lawan, Jeerus Sucharitakul, Chadaporn Kantiwiriyawanitch, Jiri Damborsky, Penchit Chitnumsub, Karl Heinz van Pée, Pimchai Chaiyen
Published 2022

Catalytic and structural insights into a stereospecific and thermostable class II aldolase HpaI from Acinetobacter baumannii

by Pratchaya Watthaisong, Asweena Binlaeh, Aritsara Jaruwat, Narin Lawan, Jirawat Tantipisit, Juthamas Jaroensuk, Litavadee Chuaboon, Jittima Phonbuppha, Ruchanok Tinikul, Pimchai Chaiyen, Penchit Chitnumsub, Somchart Maenpuen
Published 2022

A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

by Sakunrat Ubonprasert, Juthamas Jaroensuk, Wichai Pornthanakasem, Nuntaporn Kamonsutthipaijit, Peerapong Wongpituk, Pitchayathida Mee-Udorn, Thanyada Rungrotmongkol, Onuma Ketchart, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen, Somchart Maenpuen
Published 2020

Structures of Plasmodium vivax serine hydroxymethyltransferase: Implications for ligand-binding specificity and functional control

by Penchit Chitnumsub, Aritsara Jaruwat, Pinpunya Riangrungroj, Wanwipa Ittarat, Krittikar Noytanom, Worrapoj Oonanant, Jarunee Vanichthanankul, Phimonphan Chuankhayan, Somchart Maenpuen, Chun Jung Chen, Pimchai Chaiyen, Yongyuth Yuthavong, Ubolsree Leartsakulpanich
Published 2018

Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold

by Geoffrey Schwertz, Matthias C. Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Watcharee Amornwatcharapong, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Pimchai Chaiyen, François Diederich
Published 2019