A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

• Main Authors: Sakunrat Ubonprasert, Juthamas Jaroensuk, Wichai Pornthanakasem, Nuntaporn Kamonsutthipaijit, Peerapong Wongpituk, Pitchayathida Mee-Udorn, Thanyada Rungrotmongkol, Onuma Ketchart, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen, Somchart Maenpuen
• Other Authors: Vidyasirimedhi Institute of Science and Technology
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/50400
• Institution: Mahidol University

© 2019 Ubonprasert et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. Humancytosolic serine hydroxymethyltransferase (hcSHMT) is a promising target for anticancer chemotherapy and contains a flexible "flap motif" whose function is...