Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

• Main Authors: Rongbao Li, Rachada Sirawaraporn, Penchit Chitnumsub, Worachart Sirawaraporn, Jason Wooden, Francis Athappilly, Stewart Turley, Wim G.J. Hol
• Other Authors: University of Washington, Seattle
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/25881
• Institution: Mahidol University

Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate and is essential for the synthesis of thymidylate, purines and several amino acids. Inhibition of the enzyme's activity leads to arrest of DNA synthesis and cell death. The enzyme has bee...