Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

by Natpasit Chaianantakul, Rachada Sirawaraporn, Worachart Sirawaraporn
Published 2018

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

by Natpasit Chaianantakul, Rachada Sirawaraporn, Worachart Sirawaraporn
Published 2017

Plasmodium falciparum: Asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant

by Worachart Sirawaraporn, Suganya Yongkiettrakul, Rachada Sirawaraporn, Yongyuth Yuthavong, Daniel V. Santi
Published 2018

Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum

by Waraporn Kasekarn, Rachada Sirawaraporn, Thippayarat Chahomchuen, Alan F. Cowman, Worachart Sirawaraporn
Published 2018

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

by Worachart Sirawaraporn, Tanajit Sathitkul, Rachada Sirawaraporn, Yongyuth Yuthavong, Daniel V. Santi
Published 2018

Heterologous Expression of Active Thymidylate Synthase–Dihydrofolate Reductase from Plasmodium falciparum

by Worachart Sirawaraporn, Rachada Sirawaraporn, Yongyuth Yuthavong, Alan F. Cowman, Daniel V. Santi
Published 2018

Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis

by Worachart Sirawaraporn, Rachada Sirawaraporn, Atid Chanpongsri, William R. Jacobs, Daniel V. Santi
Published 2018

Crystal structure of Mycobacterium tuberculosis 6-hydroxymethyl-7,8-dihydropteroate synthase in complex with pterin monophosphate: New insight into the enzymatic mechanism and sulf...

by Arthur M. Baca, Rachada Sirawaraporn, Stewart Turley, Worachart Sirawaraporn, Wim G.J. Hol
Published 2018

Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors

by Giulio Rastelli, Sara Pacchioni, Worachart Sirawaraporn, Rachada Sirawaraporn, Marco Daniele Parenti, Anna Maria Ferrari
Published 2018

Mutational analysis of Plasmodium falciparum dihydrofolate reductase: The role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding

by Worachart Sirawaraporn, Rachada Sirawaraporn, Suganya Yongkiettrakul, Amornpol Anuwatwora, Guilio Rastelli, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong
Published 2018

Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs

by Rongbao Li, Rachada Sirawaraporn, Penchit Chitnumsub, Worachart Sirawaraporn, Jason Wooden, Francis Athappilly, Stewart Turley, Wim G.J. Hol
Published 2018

Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme

by Legesse Adane, Shweta Bhagat, Minhajul Arfeen, Sonam Bhatia, Rachada Sirawaraporn, Worachart Sirawaraporn, Asit K. Chakraborti, Prasad V. Bharatam
Published 2018

Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites

by Alireza Sardarian, Kenneth T. Douglas, Martin Read, Paul F G Sims, John E. Hyde, Penchit Chitnumsub, Rachada Sirawaraporn, Worachart Sirawaraporn
Published 2018