Identification of a Hotspot Residue for Improving the Thermostability of a Flavin-Dependent Monooxygenase

بواسطة Pornkanok Pongpamorn, Pratchaya Watthaisong, Panu Pimviriyakul, Aritsara Jaruwat, Narin Lawan, Penchit Chitnumsub, Pimchai Chaiyen
منشور في 2020

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

بواسطة Penchit Chitnumsub, Wanwipa Ittarat, Aritsara Jaruwat, Krittikar Noytanom, Watcharee Amornwatcharapong, Wichai Pornthanakasem, Pimchai Chaiyen, Yongyuth Yuthavong, Ubolsree Leartsakulpanich
منشور في 2018

Catalytic and structural insights into a stereospecific and thermostable class II aldolase HpaI from Acinetobacter baumannii

بواسطة Pratchaya Watthaisong, Asweena Binlaeh, Aritsara Jaruwat, Narin Lawan, Jirawat Tantipisit, Juthamas Jaroensuk, Litavadee Chuaboon, Jittima Phonbuppha, Ruchanok Tinikul, Pimchai Chaiyen, Penchit Chitnumsub, Somchart Maenpuen
منشور في 2022

Structures of Plasmodium vivax serine hydroxymethyltransferase: Implications for ligand-binding specificity and functional control

بواسطة Penchit Chitnumsub, Aritsara Jaruwat, Pinpunya Riangrungroj, Wanwipa Ittarat, Krittikar Noytanom, Worrapoj Oonanant, Jarunee Vanichthanankul, Phimonphan Chuankhayan, Somchart Maenpuen, Chun Jung Chen, Pimchai Chaiyen, Yongyuth Yuthavong, Ubolsree Leartsakulpanich
منشور في 2018

Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold

بواسطة Geoffrey Schwertz, Matthias C. Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Watcharee Amornwatcharapong, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Pimchai Chaiyen, François Diederich
منشور في 2019

Dissecting the low catalytic capability of flavin-dependent halogenases

بواسطة Aisaraphon Phintha, Kridsadakorn Prakinee, Aritsara Jaruwat, Narin Lawan, Surawit Visitsatthawong, Chadaporn Kantiwiriyawanitch, Warangkhana Songsungthong, Duangthip Trisrivirat, Pirom Chenprakhon, Adrian Mulholland, Karl Heinz van Pée, Penchit Chitnumsub, Pimchai Chaiyen
منشور في 2022

Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs

بواسطة Geoffrey Schwertz, Michelle S. Frei, Matthias C. Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Kerstin Mark, Pimchai Chaiyen, François Diederich
منشور في 2018

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

بواسطة Geoffrey Schwertz, Matthias C. Witschel, Matthias Rottmann, Roger Bonnert, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Susan A. Charman, Karen L. White, Abhijit Kundu, Surajit Sadhukhan, Mel Lloyd, Gail M. Freiberg, Myron Srikumaran, Marc Siggel, Adrian Zwyssig, Pimchai Chaiyen, François Diederich
منشور في 2018

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): Cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities

بواسطة Matthias C. Witschel, Matthias Rottmann, Anatol Schwab, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Michael Seet, Sandro Tonazzi, Geoffrey Schwertz, Frank Stelzer, Thomas Mietzner, Case McNamara, Frank Thater, Céline Freymond, Aritsara Jaruwat, Chatchadaporn Pinthong, Pinpunya Riangrungroj, Mouhssin Oufir, Matthias Hamburger, Pascal Mäser, Laura M. Sanz-Alonso, Susan Charman, Sergio Wittlin, Yongyuth Yuthavong, Pimchai Chaiyen, François Diederich
منشور في 2018