Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs

Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and te...

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Bibliographic Details
Main Authors: Geoffrey Schwertz, Michelle S. Frei, Matthias C. Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Kerstin Mark, Pimchai Chaiyen, François Diederich
Other Authors: ETH Zurich
Format: Article
Published: 2018
Subjects:
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/42196
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/42196

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