Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor

by Sorrentino, Vincenzo, Zelcer, Noam
Published 2024

Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

by Sorrentino, Vincenzo, Scheer, Lilith, Santos, Ana, Reits, Eric, Bleijlevens, Boris, Zelcer, Noam
Published 2024

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

by Sorrentino, Vincenzo, Nelson, Jessica K, Maspero, Elena, Marques, Andre RA, Scheer, Lilith, Polo, Simona, Zelcer, Noam
Published 2024

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL

by Nelson, Jessica Kristine, Sorrentino, Vincenzo, Trezza, Rossella Avagliano, Heride, Claire, Urbe, Sylvie, Distel, Ben, Zelcer, Noam
Published 2024

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

by Cook, Emma CL, Nelson, Jessica K, Sorrentino, Vincenzo, Koenis, Duco, Moeton, Martina, Scheij, Saskia, Ottenhoff, Roelof, Bleijlevens, Boris, Loregger, Anke, Zelcer, Noam
Published 2024

Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein

by Sorrentino, Vincenzo, Fouchier, Sigrid W, Motazacker, Mohammad M, Nelson, Jessica K, Defesche, Joep C, Dallinga-Thie, Geesje M, Kastelein, John JP, Hovingh, G Kees, Zelcer, Noam
Published 2024

LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P

by Hakonen, Johanna E, Sorrentino, Vincenzo, Trezza, Rossella Avagliano, de Wissel, Marit B, van den Berg, Marlene, Bleijlevens, Boris, van Ruissen, Fred, Distel, Ben, Baas, Frank, Zelcer, Noam, Weterman, Marian AJ
Published 2024

Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism

by Lu, Xifeng, Meima, Marcel E, Nelson, Jessica K, Sorrentino, Vincenzo, Loregger, Anke, Scheij, Saskia, Dekkers, Dick HW, Mulder, Monique T, Demmers, Jeroen AA, M-Dallinga-Thie, Geesje, Zelcer, Noam, Danser, AH Jan
Published 2024

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

by van Loon, Nienke M, Ottenhoff, Roelof, Kooijman, Sander, Moeton, Martina, Scheij, Saskia, Abbing, Reinout LP Roscam, Gijbels, Marion JJ, Levels, Johannes HM, Sorrentino, Vincenzo, Berbee, Jimmy FP, Rensen, Patrick CN, Zelcer, Noam
Published 2024

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

by Hong, Cynthia, Duit, Sarah, Jalonen, Pilvi, Out, Ruud, Scheer, Lilith, Sorrentino, Vincenzo, Boyadjian, Rima, Rodenburg, Kees W, Foley, Edan, Korhonen, Laura, Lindholm, Dan, Nimpf, Johannes, van Berkel, Theo JC, Tontonoz, Peter, Zelcer, Noam
Published 2024

A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy

by Weterman, Marian AJ, Sorrentino, Vincenzo, Kasher, Paul R, Jakobs, Marja E, van Engelen, Baziel GM, Fluiter, Kees, de Wissel, Marit B, Sizarov, Aleksander, Nuernberg, Gudrun, Nuernberg, Peter, Zelcer, Noam, Schelhaas, H Jurgen, Baas, Frank
Published 2024