#TITLE_ALTERNATIVE#
Epilepsy is a disorder that causes patients to experience seizures repeatedly. One of the drugs that <br /> <br /> could be used to treat epilepsy is . However, in the market is available as 100 mg capsule. Therefore, <br /> <br /> it is necessary for pediatric patients to pr...
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| Main Author: | |
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/28584 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Epilepsy is a disorder that causes patients to experience seizures repeatedly. One of the drugs that <br />
<br />
could be used to treat epilepsy is . However, in the market is available as 100 mg capsule. Therefore, <br />
<br />
it is necessary for pediatric patients to prepare divided powders for dose individualization. The <br />
<br />
purpose of this study was to evaluate weight variability and content uniformity that was prepared by <br />
<br />
hospital staff and design an intervention procedure to improve the outcome of the divided powders. <br />
<br />
Three pharmacy assistants in the studied hospital participated in this current study to prepare 10 <br />
<br />
divided powders for the dose of 15 mg and 50 mg, and one staff also prepared 28 divided powders for <br />
<br />
both doses. The process was repeated 3 times in different days for each staff. All samples were <br />
<br />
evaluated for its content using spectrophotometer ultraviolet. Intervention procedure was evaluated by <br />
<br />
Analytical Hierarchy Process method to choose the balances. The results showed that from the <br />
<br />
preparation of 10 divided powders of 15 mg and 50 mg doses, there were 34.44% and 61.11% of <br />
<br />
samples which met the requirement, respectively. Whereas from larger number of divided powder <br />
<br />
preparations, there was a decrease in a number of samples which met the requirement but there was no <br />
<br />
significant differences (p >0.05). From the samples of 15 mg and 50 mg doses only 39.39% and <br />
<br />
50.00 % of samples met the requirement, respectively. From the intervention study, the samples <br />
<br />
prepared using digital balance for the dose of 50 mg and 15 mg all met the requirement, whether it was <br />
<br />
prepared as 10 or 28 wraps. Results from the 10 wrap preparation using manual balance showed that <br />
<br />
were only 63.33% and 86.67% of the samples that requirement of the15 mg and 50 mg doses, <br />
<br />
respectively; and from 28 wrap preparation for the dose 15 mg and 50 mg there were 48.21% and <br />
<br />
80.36% of samples met the requirement. This study showed that it is important to prepare the divided <br />
<br />
powders using the digital balance for a narrow therapeutic index drug, such as . <br />
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