The Effect of NaCl Concentration on Salt Leaching Method on Porosity of Scaffold Based on Chitosan - Nanocellulose for Biomedical Application of Corneal

• Main Author: DASATI (NIM : 13314024) - LELY FIRDA ANGGRAENI (NIM : 13314036), OKMATIAR
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29871
• Institution: Institut Teknologi Bandung

<p align="justify"> <br /> <br /> Corneal damage is the second leading cause of blindness in the world. However, the healing solution of corneal damage can only be done by corneal transplantation (keraptoplasty). Moreover the availability of corneal donors are not sufficient for transplantation, 30% of keraptoplasty are rejected, and 5-7% of them fail. Recently, researchers are taking an interesting approach in repairing and replacing broken handles through the development of tissue engineering. The application of tissue engineering requires high-porosity of artificial extracellular matrix (scaffold). To trigger the growth of damaged cells and tissue regeneration. So in this final project, chitosan-nanocellulose-based scaffold was made by using salt leaching method. The use of chitosan and nanocellulose for the fabrication of scaffold in accordance with the nature of biocompatible and biodegradable, transparent and non-toxic extracellular matrix so it is safe to planted in human body. In this study, the salt concentration of NaCl that has been crystallized will be varied to determine the effect on the resulting scaffold porosity. Scaffold produced with SEM for particle morphology analysis, FTIR for analysis of functional groups contained, UV-Vis spectroscopy for analysis of optical properties (transparency), tensile stress for analysis of mechanical properties and swelling testing for water absorption analysis. <br /> <p align="justify">