HOMOLOGY MODELING, DOCKING, VIRTUAL SCREENING AND MOLECULAR DINAMIC STUDY OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) WITH RESISTANCE MUTATIONS OF L858R/T790M/L718Q TO ALLOSTERIC INHIBITOR ACTIVITY
The third generation of TKIs-EGFR (Tirosin Kinese Inhibitors-Epidermal Growth Factor Receptor) underwent 2 resistance mutations that are C797S and L718Q. EGFR-C797S has been overcome with allosteric inhibitor i.e. EAI001. However, its activity on the EGFR-L718Q mutation is still unknown. The aim...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/36941 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |