Cephastigiamide A, and Antiplasmodial Activity of Cephalotaxus Alkaloids from Cephalotaxus harringtonia Forma Fastigiata

• Main Authors: Hiroshi Morita, -, Yuta Nagakura, -, Takahiro Hosoya, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Kanami Mori-Yasumoto, -, Setsuko Sekita, -, Yusuke Hirasawa, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Japan Institute of Heterocyclic Chemistry 2009
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/116550/1/C-16_artikel.pdf; https://repository.unair.ac.id/116550/2/C-16_peer%20review.pdf; https://repository.unair.ac.id/116550/3/C-16_similarity.pdf; https://repository.unair.ac.id/116550/; https://www.heterocycles.jp/newlibrary/libraries/abst/21147
• Institution: Universitas Airlangga

A new Cephalotaxus alkaloid, cephastigiamide A (1), has been isolated from the leaves of Cephalotaxus harringtonia forma fastigiata and the structure was elucidated by 2D NMR analysis and chemical degradation. Harringtonine, deoxyharringtonine, and homodeoxyharringtonine showed pronounced antiplasmo...