Cephastigiamide A, and Antiplasmodial Activity of Cephalotaxus Alkaloids from Cephalotaxus harringtonia Forma Fastigiata

• Main Authors: Hiroshi Morita, -, Yuta Nagakura, -, Takahiro Hosoya, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Kanami Mori-Yasumoto, -, Setsuko Sekita, -, Yusuke Hirasawa, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Japan Institute of Heterocyclic Chemistry 2009
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/116550/1/C-16_artikel.pdf; https://repository.unair.ac.id/116550/2/C-16_peer%20review.pdf; https://repository.unair.ac.id/116550/3/C-16_similarity.pdf; https://repository.unair.ac.id/116550/; https://www.heterocycles.jp/newlibrary/libraries/abst/21147
• Institution: Universitas Airlangga

A new Cephalotaxus alkaloid, cephastigiamide A (1), has been isolated from the leaves of Cephalotaxus harringtonia forma fastigiata and the structure was elucidated by 2D NMR analysis and chemical degradation. Harringtonine, deoxyharringtonine, and homodeoxyharringtonine showed pronounced antiplasmodial activity against Plasmodium falciparum 3D7 but not against Leishmania major. Structure-activity relationship for antiplasmodial activity of isolated Cephalotaxus alkaloids was also discussed.