Cephastigiamide A, and Antiplasmodial Activity of Cephalotaxus Alkaloids from Cephalotaxus harringtonia Forma Fastigiata

Cephastigiamide A, and Antiplasmodial Activity of Cephalotaxus Alkaloids from Cephalotaxus harringtonia Forma Fastigiata

A new Cephalotaxus alkaloid, cephastigiamide A (1), has been isolated from the leaves of Cephalotaxus harringtonia forma fastigiata and the structure was elucidated by 2D NMR analysis and chemical degradation. Harringtonine, deoxyharringtonine, and homodeoxyharringtonine showed pronounced antiplasmo...

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Bibliographic Details
Main Authors: Hiroshi Morita, -, Yuta Nagakura, -, Takahiro Hosoya, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Kanami Mori-Yasumoto, -, Setsuko Sekita, -, Yusuke Hirasawa, -
Format: Article PeerReviewed
Language:English
English
English
Published: Japan Institute of Heterocyclic Chemistry 2009
Subjects:
R Medicine
RS Pharmacy and materia medica
RS1-441 Pharmacy and materia medica
RS200-201 Pharmaceutical dosage forms
Online Access:https://repository.unair.ac.id/116550/1/C-16_artikel.pdf
https://repository.unair.ac.id/116550/2/C-16_peer%20review.pdf
https://repository.unair.ac.id/116550/3/C-16_similarity.pdf
https://repository.unair.ac.id/116550/
https://www.heterocycles.jp/newlibrary/libraries/abst/21147
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Institution: Universitas Airlangga
Language: English
English
English
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Summary:A new Cephalotaxus alkaloid, cephastigiamide A (1), has been isolated from the leaves of Cephalotaxus harringtonia forma fastigiata and the structure was elucidated by 2D NMR analysis and chemical degradation. Harringtonine, deoxyharringtonine, and homodeoxyharringtonine showed pronounced antiplasmodial activity against Plasmodium falciparum 3D7 but not against Leishmania major. Structure-activity relationship for antiplasmodial activity of isolated Cephalotaxus alkaloids was also discussed.

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