Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis
Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. Objective: In this research, we employed an in...
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| Main Authors: | , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English English English |
| Published: |
PagePress Publications
2023
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| Online Access: | https://repository.unair.ac.id/125405/1/C-08_artikel.pdf https://repository.unair.ac.id/125405/2/Kualitas%20Karil%20C-08.pdf https://repository.unair.ac.id/125405/3/C-08_similarity.pdf https://repository.unair.ac.id/125405/4/C-08%20korespodensi.pdf https://repository.unair.ac.id/125405/9/Korespondensi%20C-07%20rev.pdf https://repository.unair.ac.id/125405/ https://www.publichealthinafrica.org/jphia/article/view/2506 https://doi.org/10.4081/jphia.2023.2506 |
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| Institution: | Universitas Airlangga |
| Language: | English English English English English |
| Summary: | Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory.
Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA.
Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia.
Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia.
Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy. |
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