Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis
Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. Objective: In this research, we employed an in...
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id-langga.1254052023-05-30T07:10:34Z https://repository.unair.ac.id/125405/ Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis Riza Ambar Sari, - Fina Luthfiana, - Irawati Sholihah, - Katsuyoshi Matsunami, - Sukardiman, - Retno Widyowati, - R Medicine RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA. Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia. Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia. Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy. PagePress Publications 2023-03-16 Article PeerReviewed text en https://repository.unair.ac.id/125405/1/C-08_artikel.pdf text en https://repository.unair.ac.id/125405/2/Kualitas%20Karil%20C-08.pdf text en https://repository.unair.ac.id/125405/3/C-08_similarity.pdf text en https://repository.unair.ac.id/125405/4/C-08%20korespodensi.pdf text en https://repository.unair.ac.id/125405/9/Korespondensi%20C-07%20rev.pdf Riza Ambar Sari, - and Fina Luthfiana, - and Irawati Sholihah, - and Katsuyoshi Matsunami, - and Sukardiman, - and Retno Widyowati, - (2023) Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis. Journal of Public Health in Africa, 14 (S1). ISSN 2038-9922 https://www.publichealthinafrica.org/jphia/article/view/2506 https://doi.org/10.4081/jphia.2023.2506 |
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R Medicine RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Riza Ambar Sari, - Fina Luthfiana, - Irawati Sholihah, - Katsuyoshi Matsunami, - Sukardiman, - Retno Widyowati, - Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis |
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Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory.
Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA.
Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia.
Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia.
Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy. |
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Article PeerReviewed |
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Riza Ambar Sari, - Fina Luthfiana, - Irawati Sholihah, - Katsuyoshi Matsunami, - Sukardiman, - Retno Widyowati, - |
author_facet |
Riza Ambar Sari, - Fina Luthfiana, - Irawati Sholihah, - Katsuyoshi Matsunami, - Sukardiman, - Retno Widyowati, - |
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Riza Ambar Sari, - |
title |
Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis |
title_short |
Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis |
title_full |
Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis |
title_fullStr |
Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis |
title_full_unstemmed |
Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. Bulb on rats monosodium iodoacetate-induced osteoarthritis |
title_sort |
antiosteoarthritis activities of 70% ethanol extract of eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis |
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PagePress Publications |
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2023 |
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https://repository.unair.ac.id/125405/1/C-08_artikel.pdf https://repository.unair.ac.id/125405/2/Kualitas%20Karil%20C-08.pdf https://repository.unair.ac.id/125405/3/C-08_similarity.pdf https://repository.unair.ac.id/125405/4/C-08%20korespodensi.pdf https://repository.unair.ac.id/125405/9/Korespondensi%20C-07%20rev.pdf https://repository.unair.ac.id/125405/ https://www.publichealthinafrica.org/jphia/article/view/2506 https://doi.org/10.4081/jphia.2023.2506 |
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