Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukimia
Abstract Objective: To analyze the Total Neuropathy Scale Pediatric Vincristine (TNS-PV) score as a vincristine induced peripheral neuropathy (VIPN) diagnostic tool. Methodology: This observational analytic study was conducted in Outpatient Pediatric Hematology Oncology Dr. Soetomo Hospital. The in...
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Main Authors: | , , |
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Format: | Article PeerReviewed |
Language: | English Indonesian English English Indonesian |
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Pakistan Medical Association Rawalpindi Islamabad Branch, Rawalpindi, Pakistan
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Online Access: | https://repository.unair.ac.id/125779/1/Artikel.pdf https://repository.unair.ac.id/125779/2/7.%20Karil.pdf https://repository.unair.ac.id/125779/3/5.%20Turnitin.pdf https://repository.unair.ac.id/125779/4/4.%20Bukti%20Korespondensi.pdf https://repository.unair.ac.id/125779/5/6.%20Etik.pdf https://repository.unair.ac.id/125779/ https://www.rmj.org.pk/fulltext/27-1655155391.pdf?1678066462 http://dx.doi.org/10.5455/rmj20220613092311 |
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Institution: | Universitas Airlangga |
Language: | English Indonesian English English Indonesian |
Summary: | Abstract
Objective: To analyze the Total Neuropathy Scale Pediatric Vincristine (TNS-PV) score as a vincristine induced peripheral neuropathy (VIPN) diagnostic tool. Methodology: This observational analytic study was conducted in Outpatient Pediatric Hematology Oncology Dr. Soetomo Hospital. The inclusion criteria were Acute Lymphoblastic Leukemia (ALL) children aged 4 – 18 years that had undergone chemotherapy treatment, received a cumulative dose of vincristine > 12 mg/m2, had no muscle weakness and signed informed consent. The TNS-PV instrument were used to assess VIPN and nerve conduction studies (NCS) was used as the gold standard. Results: A total of 54 children were enrolled, two refused to sign the informed consent. About 60% were male children, 76.9% aged < 10 years old, and 94% were ALL-L1. The TNS-PV had an area under the curve (AUC) of 0.638 (95% CI 0.531-0.834) with cut off value of 3.5. It had a sensitivity 87.9%; specificity 42.1%, positive predictive value 72.5%; negative predictive value (NPV) 66.6% and OR (Odds ratio) 5,273. Conclusion: TNS-PV score cannot replace NCS as the gold standard, but TNS-PV can be an alternative tool for diagnosing VIPN. |
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