Understanding the role of drug efflux transporters in vincristine-resistant acute lymphoblastic leukaemia cells.

• Main Author: Tania Hussaini.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/52941
• Institution: Nanyang Technological University

Cell proliferation is an integral process in ensuring leukemic cell survival. Microtubules, essential cytoskeleton components and important players in mitosis, makes them effective therapeutic target in leukaemia. The vinca alkaloid, vincristine (VCR), specifically disrupts microtubule dynamics, cau...