Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukimia

• Main Authors: Prastiya Indra Gunawan, Prastiya, Kartika Hardiyani, -, I. Dewa Gede Ugrasena, -
• Format: Article PeerReviewed
• Language: English; Indonesian; English; English; Indonesian
• Published: Pakistan Medical Association Rawalpindi Islamabad Branch, Rawalpindi, Pakistan
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/125779/1/Artikel.pdf; https://repository.unair.ac.id/125779/2/7.%20Karil.pdf; https://repository.unair.ac.id/125779/3/5.%20Turnitin.pdf; https://repository.unair.ac.id/125779/4/4.%20Bukti%20Korespondensi.pdf; https://repository.unair.ac.id/125779/5/6.%20Etik.pdf; https://repository.unair.ac.id/125779/; https://www.rmj.org.pk/fulltext/27-1655155391.pdf?1678066462; http://dx.doi.org/10.5455/rmj20220613092311
• Institution: Universitas Airlangga

Abstract Objective: To analyze the Total Neuropathy Scale Pediatric Vincristine (TNS-PV) score as a vincristine induced peripheral neuropathy (VIPN) diagnostic tool. Methodology: This observational analytic study was conducted in Outpatient Pediatric Hematology Oncology Dr. Soetomo Hospital. The inclusion criteria were Acute Lymphoblastic Leukemia (ALL) children aged 4 – 18 years that had undergone chemotherapy treatment, received a cumulative dose of vincristine > 12 mg/m2, had no muscle weakness and signed informed consent. The TNS-PV instrument were used to assess VIPN and nerve conduction studies (NCS) was used as the gold standard. Results: A total of 54 children were enrolled, two refused to sign the informed consent. About 60% were male children, 76.9% aged < 10 years old, and 94% were ALL-L1. The TNS-PV had an area under the curve (AUC) of 0.638 (95% CI 0.531-0.834) with cut off value of 3.5. It had a sensitivity 87.9%; specificity 42.1%, positive predictive value 72.5%; negative predictive value (NPV) 66.6% and OR (Odds ratio) 5,273. Conclusion: TNS-PV score cannot replace NCS as the gold standard, but TNS-PV can be an alternative tool for diagnosing VIPN.