In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

• Main Authors: Saipul Maulana, -, Tutik Sri Wahyuni, -, Prihartini Widiyanti, -
• Format: Article NonPeerReviewed
• Language: English; English
• Published: 2023
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: https://repository.unair.ac.id/126834/1/Turnitin%20In%20silico%20screening.pdf; https://repository.unair.ac.id/126834/2/Artikel.pdf; https://repository.unair.ac.id/126834/; https://web.s.ebscohost.com/abstract?site=ehost&scope=site&jrnl=20389922&AN=163012298&h=maft4p7EvmfoUZBIuVKdB7tIpSN1CTn4DuEuHyTS2hibLDSupkZ5%2fBWMxYDB4KDPREi5j3UgaKWOAoiVge6TxQ%3d%3d&crl=f&resultLocal=ErrCrlNoResults&resultNs=Ehost&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d20389922%26AN%3d163012298
• Institution: Universitas Airlangga

Background: The emergence of Coronavirus disease (COVID-19) has been declared a pandemic and made a medical emergency worldwide. Various attempts have been made, including optimizing effective treatments against the disease or developing a vaccine. Since the SARS-CoV-2 protease crystal structure has been discovered, searching for its inhibitors by in silico technique becomes possible. Objective: This study aims to virtually screen the potential of phytoconstituents from the Begonia genus as 3Cl pro-SARS CoV- 2 inhibitors, based on its crucial role in viral replication, hence making these proteases “promising” for the anti-SARS-CoV-2 target.