Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin
Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
Dr. Yashwant Research Labs Pvt. Ltd.
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/88076/3/Artikel%20C-13.pdf http://repository.unair.ac.id/88076/1/C-13%20Result%20-%20Penetration%20of%20Ubiquinone%20%28Q10%29%20Nanoemulsion%20Using%20Olive%20Oil%20Through%20Rat%20Skin.pdf http://repository.unair.ac.id/88076/4/C-13%20Reviewer.pdf http://repository.unair.ac.id/88076/ http://impactfactor.org/PDF/IJPCR/9/IJPCR,Vol9,Issue2,Article12.pdf |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In addition, it was conducted a penetration test of Q10 in nanoemulsion delivery system compared to Q10 in emulsion using male Wistar rats. From the characterization results, it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) < Q10 emulsion (21.063 ± 3,57μm), the morphology of droplet Q10 nanoemulsion and Q10 emulsion that are spherical, and that the viscosity of Q10 nanoemulsion (10.5 CPa.s) < Q10 emulsion (16 CPa.s). The penetration rate of Q10 in nanoemulsion and emulsion was observed at 2 hours, 4 hours, and 6 hours after treatment. The result was known that the penetration rate of Q10 in nanoemulsion (174.49 μm/h) > Q10 in emulsion (20.429 μm/h). |
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