Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin
Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In...
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Dr. Yashwant Research Labs Pvt. Ltd.
2017
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Online Access: | http://repository.unair.ac.id/88076/3/Artikel%20C-13.pdf http://repository.unair.ac.id/88076/1/C-13%20Result%20-%20Penetration%20of%20Ubiquinone%20%28Q10%29%20Nanoemulsion%20Using%20Olive%20Oil%20Through%20Rat%20Skin.pdf http://repository.unair.ac.id/88076/4/C-13%20Reviewer.pdf http://repository.unair.ac.id/88076/ http://impactfactor.org/PDF/IJPCR/9/IJPCR,Vol9,Issue2,Article12.pdf |
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id-langga.880762020-01-06T02:51:48Z http://repository.unair.ac.id/88076/ Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin Deapsari F Tristiana Erawati Widji Soeratri R Medicine RS Pharmacy and materia medica Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In addition, it was conducted a penetration test of Q10 in nanoemulsion delivery system compared to Q10 in emulsion using male Wistar rats. From the characterization results, it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) < Q10 emulsion (21.063 ± 3,57μm), the morphology of droplet Q10 nanoemulsion and Q10 emulsion that are spherical, and that the viscosity of Q10 nanoemulsion (10.5 CPa.s) < Q10 emulsion (16 CPa.s). The penetration rate of Q10 in nanoemulsion and emulsion was observed at 2 hours, 4 hours, and 6 hours after treatment. The result was known that the penetration rate of Q10 in nanoemulsion (174.49 μm/h) > Q10 in emulsion (20.429 μm/h). Dr. Yashwant Research Labs Pvt. Ltd. 2017-02-25 Article PeerReviewed text en http://repository.unair.ac.id/88076/3/Artikel%20C-13.pdf text en http://repository.unair.ac.id/88076/1/C-13%20Result%20-%20Penetration%20of%20Ubiquinone%20%28Q10%29%20Nanoemulsion%20Using%20Olive%20Oil%20Through%20Rat%20Skin.pdf text en http://repository.unair.ac.id/88076/4/C-13%20Reviewer.pdf Deapsari F and Tristiana Erawati and Widji Soeratri (2017) Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin. International Journal of Pharmaceutical and Clinical Research, 9 (2). pp. 169-172. ISSN 0975-1556 http://impactfactor.org/PDF/IJPCR/9/IJPCR,Vol9,Issue2,Article12.pdf 10.25258/ijpcr.v9i1.8300 |
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R Medicine RS Pharmacy and materia medica Deapsari F Tristiana Erawati Widji Soeratri Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin |
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Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In addition, it was conducted a penetration test of Q10 in nanoemulsion delivery system compared to Q10 in emulsion using male Wistar rats. From the characterization results, it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) < Q10 emulsion (21.063 ± 3,57μm), the morphology of droplet Q10 nanoemulsion and Q10 emulsion that are spherical, and that the viscosity of Q10 nanoemulsion (10.5 CPa.s) < Q10 emulsion (16 CPa.s). The penetration rate of Q10 in nanoemulsion and emulsion was observed at 2 hours, 4 hours, and 6 hours after treatment. The result was known that the penetration rate of Q10 in nanoemulsion (174.49 μm/h) > Q10 in emulsion (20.429 μm/h). |
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Article PeerReviewed |
author |
Deapsari F Tristiana Erawati Widji Soeratri |
author_facet |
Deapsari F Tristiana Erawati Widji Soeratri |
author_sort |
Deapsari F |
title |
Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin |
title_short |
Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin |
title_full |
Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin |
title_fullStr |
Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin |
title_full_unstemmed |
Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin |
title_sort |
penetration of ubiquinone (q10) nanoemulsion using olive oil through rat skin |
publisher |
Dr. Yashwant Research Labs Pvt. Ltd. |
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2017 |
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http://repository.unair.ac.id/88076/3/Artikel%20C-13.pdf http://repository.unair.ac.id/88076/1/C-13%20Result%20-%20Penetration%20of%20Ubiquinone%20%28Q10%29%20Nanoemulsion%20Using%20Olive%20Oil%20Through%20Rat%20Skin.pdf http://repository.unair.ac.id/88076/4/C-13%20Reviewer.pdf http://repository.unair.ac.id/88076/ http://impactfactor.org/PDF/IJPCR/9/IJPCR,Vol9,Issue2,Article12.pdf |
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