PENGARUH PEMBERIAN EKSTRAK MENGKUDU (Morinda citrifolia L.) �FREEZE JUICING� TERHADAP KADAR GLUKOSA DARAH TIKUS WISTAR DIABETES MELLITUS
Background: Diabetes mellitus (DM), a degenerative disease, is a metabolic disorder characterized by high levels of glucose in the blood. The prevalence of diabetes continues to rise and will be a serious health problem. Noni is an alternative functional foods that have hypoglycemic effects. Noni ha...
Saved in:
Main Authors: | , |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
|
Subjects: | |
Online Access: | https://repository.ugm.ac.id/121968/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62067 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Gadjah Mada |
Summary: | Background: Diabetes mellitus (DM), a degenerative disease, is a metabolic
disorder characterized by high levels of glucose in the blood. The prevalence of
diabetes continues to rise and will be a serious health problem. Noni is an
alternative functional foods that have hypoglycemic effects. Noni has a pungent
odor and unpleasant. Freeze juicing extraction method is an alternative to the
simple extraction to minimize the lack of it.
Objective: This study aimed to determine the effect of noni extract \"freeze
juicing\" on blood glucose levels wistar rats with diabetes mellitus.
Method: The type of this research was a quasi experimental study with a type of
design form, pre and post test control group design. Subject of this study is thirty
Wistar rats aged 2 months and weighs about 160-180 grams. Rats were divided
into 5 groups: negative control, positive control, freeze juicing noni doses of 0.25,
0.50 doses, and 1 dose during 28 days of treatment. Rats were adapted for 3
days, then fasted rats before induction of nicotinamide 110 mg and 45 mg
streptozotocin. Analysis of blood glucose level was as much as 2 times (pre and
post test). Data were analyzed using ANOVA.
The results: Wistar rats was induced by streptozotocin and nicotinamide had
increase blood glucose levels by an average blood glucose> 200 mg / dl.
Statistical tests were conducted to determine the changes in blood glucose levels
from pre-test to post test showed no significant difference between groups with
p> 0.05. Juicing freeze noni extract had no effect on blood glucose levels
decrease DM Wistar rats. Although the 0.5 dose group but decreased in the
positive control group also decreased.
Conclusions: Freeze juicing noni extract had no effect on blood glucose levels in
Wistar rats with diabetes mellitus. |
---|