A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

• Main Authors: Yeh, Lu-Yang, Fang, Yu-Ting, Lee, Hong-Sheng, Liu, Chia-Hao, Chen, You-Yin, Lo, Yu-Chun, Laiman, Vincent, Liou, Jing-Ping, Chung, Kian Fan, Chuang, Hsiao-Chi, Lin, Chien-Huang
• Format: Article PeerReviewed
• Language: English
• Published: Frontier 2022
• Subjects: Clinical Sciences
• Online Access: https://repository.ugm.ac.id/278934/1/Laiman_KKMK.pdf; https://repository.ugm.ac.id/278934/; https://www.frontiersin.org/articles/10.3389/fmed.2022.794025/full; https://doi.org/10.3389/fmed.2022.794025
• Institution: Universitas Gadjah Mada

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic mortality. The objective of this study was to investigate the therapeutic potential of a novel potent histone deacetylase (HDAC) inhibitor MPT0E028 on emphysema. Materials and Methods: A mouse model of porcine pa...