Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

• Main Authors: Cheng, Wun-Hao, Kao, Shih-Ya, Chen, Chia-Ling, Yuliani, Fara Silvia, Lin, Lee-Yuan, Lin, Chien-Huang, Chen, Bing-Chang
• Format: Article PeerReviewed
• Language: English
• Published: Springer Nature 2022
• Subjects: Cell Physiology; Systems Physiology
• Online Access: https://repository.ugm.ac.id/283164/1/s12931-022-02285-2.pdf; https://repository.ugm.ac.id/283164/; https://respiratory-research.biomedcentral.com/
• Institution: Universitas Gadjah Mada

Background Airway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)-β has been known to promote epithelial-mesenchymal transition formation and to play a role in the progression of tissue fibrosis. Cellular communication network factor 2 (CCN2)...