Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides

The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions...

Full description

Saved in:
Bibliographic Details
Main Authors: Wilkinson, Shane M., Liew, Chu W., Mackay, Joel P., Mohd. Salleh, Hamzah, Withers, Stephen G., McLeod, Malcolm D.
Format: Article
Language:English
Published: American Chemical Society 2008
Subjects:
Online Access:http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf
http://irep.iium.edu.my/23428/
http://pubs.acs.org/doi/abs/10.1021/ol8002767?journalCode=orlef7
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Universiti Islam Antarabangsa Malaysia
Language: English
Description
Summary:The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.