Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides

The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions...

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Main Authors:	Wilkinson, Shane M., Liew, Chu W., Mackay, Joel P., Mohd. Salleh, Hamzah, Withers, Stephen G., McLeod, Malcolm D.
Format:	Article
Language:	English
Published:	American Chemical Society 2008
Subjects:	T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf http://irep.iium.edu.my/23428/ http://pubs.acs.org/doi/abs/10.1021/ol8002767?journalCode=orlef7
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Institution:	Universiti Islam Antarabangsa Malaysia
Language:	English

id	my.iium.irep.23428
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spelling	my.iium.irep.234282021-07-01T10:19:41Z http://irep.iium.edu.my/23428/ Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions. American Chemical Society 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf Wilkinson, Shane M. and Liew, Chu W. and Mackay, Joel P. and Mohd. Salleh, Hamzah and Withers, Stephen G. and McLeod, Malcolm D. (2008) Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides. Organic Letters, 10 (8). pp. 1585-1588. ISSN 1523-7060 http://pubs.acs.org/doi/abs/10.1021/ol8002767?journalCode=orlef7 10.1021/ol8002767
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology
spellingShingle	T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
description	The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.
format	Article
author	Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D.
author_facet	Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D.
author_sort	Wilkinson, Shane M.
title	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_short	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_full	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_fullStr	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_full_unstemmed	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_sort	escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
publisher	American Chemical Society
publishDate	2008
url	http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf http://irep.iium.edu.my/23428/ http://pubs.acs.org/doi/abs/10.1021/ol8002767?journalCode=orlef7
_version_	1705056457197617152

Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides

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