A revisit into the Den2 NS2B/NS3 virus protease homology model: Structural verification and comparison with crystal structure of HCV NS3/4A and Den2 NS3

• Main Authors: Lee, Y.K., Othman, R., Abdul Wahab, H., Yusof, Rohana, Rahman, N.A.
• Format: Article
• Published: Faculty of Science, University of Malaya 2006
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/7139/
• Institution: Universiti Malaya

Although the crystal structure of DEN2 NS3 serine protease has been reported, the proteolytic mechanism of this enzyme in the presence of NS2B as co-factor which greatly enhances its activity is not well-understood. Using the homology model of DEN2 NS3 co-complexed with NS2B co-factor based on HCV N...