Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Contemporary Research Center, Australia
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf http://psasir.upm.edu.my/id/eprint/30288/ http://www.ijern.com/June-2013.php |
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| Institution: | Universiti Putra Malaysia |
| Language: | English English |
| Summary: | Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their
corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four
cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane
(TTMSH) and azobisisobutyronitrile (AIBN) in toluene to obtain 5-hydro-4-imino-3,6-
dimethylpyran-2-one (4a), 4-amino-5-hydro-3,6,6-trimethylpyran-2-one (4b),3,5-dihydro-4-imino-
6-methylpyran-2-one (4c), and 3,5-Dihydro-4-imino-6,6-dimethylpyran-2-one (4d). |
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