Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach

• Main Authors: Mohd Nor, Siti Mariam, Mohd Fauzi, Nawwar Fathiah, Ismail, Intan Safinar
• Format: Article
• Language: English; English
• Published: Contemporary Research Center, Australia 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf; http://psasir.upm.edu.my/id/eprint/30288/; http://www.ijern.com/June-2013.php
• Institution: Universiti Putra Malaysia

Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH...