Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach

Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach

Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH...

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Main Authors: Mohd Nor, Siti Mariam, Mohd Fauzi, Nawwar Fathiah, Ismail, Intan Safinar
Format: Article
Language:English
English
Published: Contemporary Research Center, Australia 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf
http://psasir.upm.edu.my/id/eprint/30288/
http://www.ijern.com/June-2013.php
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Institution: Universiti Putra Malaysia
Language: English
English
id my.upm.eprints.30288
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spelling my.upm.eprints.302882015-10-09T00:40:49Z http://psasir.upm.edu.my/id/eprint/30288/ Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach Mohd Nor, Siti Mariam Mohd Fauzi, Nawwar Fathiah Ismail, Intan Safinar Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH) and azobisisobutyronitrile (AIBN) in toluene to obtain 5-hydro-4-imino-3,6- dimethylpyran-2-one (4a), 4-amino-5-hydro-3,6,6-trimethylpyran-2-one (4b),3,5-dihydro-4-imino- 6-methylpyran-2-one (4c), and 3,5-Dihydro-4-imino-6,6-dimethylpyran-2-one (4d). Contemporary Research Center, Australia 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf Mohd Nor, Siti Mariam and Mohd Fauzi, Nawwar Fathiah and Ismail, Intan Safinar (2013) Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach. International Journal of Education and Research, 1 (6). ISSN 2201-6333; ESSN: 2201-6740 http://www.ijern.com/June-2013.php English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH) and azobisisobutyronitrile (AIBN) in toluene to obtain 5-hydro-4-imino-3,6- dimethylpyran-2-one (4a), 4-amino-5-hydro-3,6,6-trimethylpyran-2-one (4b),3,5-dihydro-4-imino- 6-methylpyran-2-one (4c), and 3,5-Dihydro-4-imino-6,6-dimethylpyran-2-one (4d).
format Article
author Mohd Nor, Siti Mariam
Mohd Fauzi, Nawwar Fathiah
Ismail, Intan Safinar
spellingShingle Mohd Nor, Siti Mariam
Mohd Fauzi, Nawwar Fathiah
Ismail, Intan Safinar
Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
author_facet Mohd Nor, Siti Mariam
Mohd Fauzi, Nawwar Fathiah
Ismail, Intan Safinar
author_sort Mohd Nor, Siti Mariam
title Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
title_short Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
title_full Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
title_fullStr Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
title_full_unstemmed Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
title_sort synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
publisher Contemporary Research Center, Australia
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf
http://psasir.upm.edu.my/id/eprint/30288/
http://www.ijern.com/June-2013.php
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