Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats
Introduction. Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats....
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi
2015
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| Subjects: | |
| Online Access: | http://eprints.usm.my/31564/1/SzeHan_PSC_Antidiabetic_BioMed_RI__Nov_2015_214918.pdf http://eprints.usm.my/31564/ https://www.hindawi.com/journals/bmri |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Introduction. Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological
properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC
aqueous extract in normal and diabetic rats. Materials and Methods. A single dose of 500, 750, or 1000mg/kg of the PSC extract
was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). The effective
dose (750mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in
terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles. Results.The dose of 750 mg/kg showed the most
significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study ( |
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