Synthesis and structure-activity relationship of a microcionamide-inspired peptide

• Main Authors: Inocentes, Carl Rogel V., Salvador-Reyes, Lilibeth A., Villaraza, Aaron Joseph L.
• Format: text
• Published: Animo Repository 2019
• Subjects: Peptides; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11430
• Institution: De La Salle University

Here we describe the facile synthesis of four microcionamide-inspired peptides where the atypical 2- phenylethylenamine in the marine natural product, microcionamide A, was substituted by a similarly-aromatic and more easily incorporated tryptophan residue. Compounds 1-4 were synthesized using a sta...