In silico discovery and in vitro activity of inhibitors against mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

• Main Authors: Billones, Junie B., Carrillo, Maria Constancia O., Organo, Voltaire G., Sy, Jamie Bernadette A., Clavio, Nina Abigail B., Macalino, Stephani Joy Y., Emnacen, Inno A., Lee, Alexandra P., Ko, Paul Kenny L., Concepcion, Gisela P.
• Format: text
• Published: Animo Repository 2017
• Subjects: Antitubercular agents—Computer-aided design; Antitubercular agents—Design; Mycobacterium tuberculosis—Treatment; Medicinal-Pharmaceutical Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11458
• Institution: De La Salle University

Computer-aided drug discovery and development approaches such as virtual screening, molecular docking, and in silico drug property calculations have been utilized in this effort to discover new lead compounds against tuberculosis. The enzyme 7,8-diaminopelargonic acid aminotransferase (BioA) in Myco...