Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol

• Main Authors: Cornelio, Kimberly, Espiritu, Rafael Atillo, Hanashima, Shinya, Todokoro, Yasuto, Malabed, Raymond, Kinoshita, Masanao, Matsumori, Nobuaki, Murata, Michio, Nishimura, Shinichi, Kakeya, Hideaki, Yoshida, Minoru, Matsunaga, Shigeki
• Format: text
• Published: Animo Repository 2019
• Subjects: Cyclic peptides; Antifungal agents; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1182; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2181/type/native/viewcontent
• Institution: De La Salle University

© 2018 Elsevier B.V. Theonellamides (TNMs) are antifungal and cytotoxic bicyclic dodecapeptides isolated from the marine sponge Theonella sp. The inclusion of cholesterol (Chol) or ergosterol in the phosphatidylcholine membrane is known to significantly enhance the membrane affinity for theonellamid...