Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by¹H NMR

• Main Authors: Cornelio, Kimberly, Espiritu, Rafael Atillo, Todokoro, Yasuto, Hanashima, Shinya, Kinoshita, Masanao, Matsumori, Nobuaki, Murata, Michio, Nishimura, Shinichi, Kakeya, Hideaki, Yoshida, Minoru, Matsunaga, Shigeki
• Format: text
• Published: Animo Repository 2016
• Subjects: Sponges; Cyclic peptides; Cholesterol; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/2672
• Institution: De La Salle University

Theonellamide A (TNM-A) is an antifungal bicyclic dodecapeptide isolated from a marine sponge Theonella sp. Previous studies have shown that TNM-A preferentially binds to 3β-hydroxysterol-containing membranes and disrupts membrane integrity. In this study, several1H NMR-based experiments were perfor...