Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by<sup>1</sup>H NMR

Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by<sup>1</sup>H NMR

Theonellamide A (TNM-A) is an antifungal bicyclic dodecapeptide isolated from a marine sponge Theonella sp. Previous studies have shown that TNM-A preferentially binds to 3β-hydroxysterol-containing membranes and disrupts membrane integrity. In this study, several1H NMR-based experiments were perfor...

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Main Authors: Cornelio, Kimberly, Espiritu, Rafael Atillo, Todokoro, Yasuto, Hanashima, Shinya, Kinoshita, Masanao, Matsumori, Nobuaki, Murata, Michio, Nishimura, Shinichi, Kakeya, Hideaki, Yoshida, Minoru, Matsunaga, Shigeki
Format: text
Published: Animo Repository 2016
Subjects:
Sponges
Cyclic peptides
Cholesterol
Chemistry
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/2672
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Institution: De La Salle University

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