Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol

• المؤلفون الرئيسيون: Cornelio, Kimberly, Espiritu, Rafael Atillo, Hanashima, Shinya, Todokoro, Yasuto, Malabed, Raymond, Kinoshita, Masanao, Matsumori, Nobuaki, Murata, Michio, Nishimura, Shinichi, Kakeya, Hideaki, Yoshida, Minoru, Matsunaga, Shigeki
• التنسيق: text
• منشور في: Animo Repository 2019
• الموضوعات: Cyclic peptides; Antifungal agents; Chemistry
• الوصول للمادة أونلاين: https://animorepository.dlsu.edu.ph/faculty_research/1182; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2181/type/native/viewcontent

© 2018 Elsevier B.V. Theonellamides (TNMs) are antifungal and cytotoxic bicyclic dodecapeptides isolated from the marine sponge Theonella sp. The inclusion of cholesterol (Chol) or ergosterol in the phosphatidylcholine membrane is known to significantly enhance the membrane affinity for theonellamid...